111-indium human antimyosin monoclonal antibody-fragment study on alcoholic (and diabetic) cardiomyopathic patients (ACM-DCM) with Centocor Europe Myoscint (Msc).
Identifieur interne : 005775 ( Main/Exploration ); précédent : 005774; suivant : 005776111-indium human antimyosin monoclonal antibody-fragment study on alcoholic (and diabetic) cardiomyopathic patients (ACM-DCM) with Centocor Europe Myoscint (Msc).
Auteurs : RBID : pubmed:2136360English descriptors
- KwdEn :
- Adult, Alcoholism (radionuclide imaging), Antibodies, Monoclonal (diagnostic use), Cardiomyopathy, Alcoholic (radionuclide imaging), Diabetes Mellitus (radionuclide imaging), Female, Heart (radionuclide imaging), Humans, Immunoglobulin Fab Fragments (diagnostic use), Indium Radioisotopes (diagnostic use), Lung (radionuclide imaging), Male, Middle Aged, Myocardial Infarction (radionuclide imaging), Myosins (diagnostic use), Organometallic Compounds (diagnostic use).
- MESH :
- chemical , diagnostic use : Antibodies, Monoclonal, Immunoglobulin Fab Fragments, Indium Radioisotopes, Myosins, Organometallic Compounds.
- radionuclide imaging : Alcoholism, Cardiomyopathy, Alcoholic, Diabetes Mellitus, Heart, Lung, Myocardial Infarction.
- Adult, Female, Humans, Male, Middle Aged.
Abstract
The criteria of Msc-positivity were: typical accumulation of hot spots in 2 directions of planar scan in the 24-48-hr measurements, while in atypical cases the hot spots were present only in the 48 hr picture. Twenty-one male volunteers were assessed. 18 of them had ACM (2 patients were studied repeatedly). The negative and positive control cases exhibited the expected Msc pattern. Seven ACM patients were regarded typically positive, in 5 cases atypical positivity was stated, and 6 patients were classified as Msc negatives. The heart lung activity ratio was 1.75 +/- 0.45 and 1.68 +/- 0.44 for typical and atypical positive cases, respectively. The control and DCM H/L ratios were 1.15 and 1.3 +/- 0.2, respectively, in AMI the H/L was 1.91, in DCM of dilatative phase it was 1.55 +/- 0.06 with serum myosin in the normal range. Heart dilation in the DCM groups: 5 dilated out of 7 typically positive cases while in atypically positive, and negative cases the dilation occurred in 2 out of 5 and 1 out of 6 cases, respectively. Low LV-EF (less than 45%) were found in ratios of 4/7, 2/5, and 1/6 in typically positive, atypically positive and negative cases, respectively. Elevated PCP similar ratios. In the same groups pathological ECG was seen in ratios of 5/7, 1/5, and 1/6, respectively. The g-GT activity was enhanced in all cases, there was, however, no evident correlation between the actual enzyme activity and intensity of hot accumulation.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed: 2136360
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">111-indium human antimyosin monoclonal antibody-fragment study on alcoholic (and diabetic) cardiomyopathic patients (ACM-DCM) with Centocor Europe Myoscint (Msc).</title><author><name sortKey="Horv Th, M" uniqKey="Horv Th M">M Horváth</name><affiliation wicri:level="1"><nlm:affiliation>State Hospital for Cardiology, Balatonfüred, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>State Hospital for Cardiology, Balatonfüred</wicri:regionArea></affiliation></author><author><name sortKey="Pszota, A" uniqKey="Pszota A">A Pszota</name></author><author><name sortKey="K Rm N, M" uniqKey="K Rm N M">M Kármán</name></author><author><name sortKey="B Sz Rmenyi, E" uniqKey="B Sz Rmenyi E">E Böszörményi</name></author><author><name sortKey="Raki S, F" uniqKey="Raki S F">F Rakiás</name></author><author><name sortKey="Bodor, M" uniqKey="Bodor M">M Bodor</name></author><author><name sortKey="P L, T" uniqKey="P L T">T Pál</name></author></titleStmt><publicationStmt><date when="1990">1990</date><idno type="RBID">pubmed:2136360</idno><idno type="pmid">2136360</idno><idno type="wicri:Area/Main/Corpus">005B29</idno><idno type="wicri:Area/Main/Curation">005B29</idno><idno type="wicri:Area/Main/Exploration">005775</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Alcoholism (radionuclide imaging)</term><term>Antibodies, Monoclonal (diagnostic use)</term><term>Cardiomyopathy, Alcoholic (radionuclide imaging)</term><term>Diabetes Mellitus (radionuclide imaging)</term><term>Female</term><term>Heart (radionuclide imaging)</term><term>Humans</term><term>Immunoglobulin Fab Fragments (diagnostic use)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Lung (radionuclide imaging)</term><term>Male</term><term>Middle Aged</term><term>Myocardial Infarction (radionuclide imaging)</term><term>Myosins (diagnostic use)</term><term>Organometallic Compounds (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Immunoglobulin Fab Fragments</term><term>Indium Radioisotopes</term><term>Myosins</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Alcoholism</term><term>Cardiomyopathy, Alcoholic</term><term>Diabetes Mellitus</term><term>Heart</term><term>Lung</term><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The criteria of Msc-positivity were: typical accumulation of hot spots in 2 directions of planar scan in the 24-48-hr measurements, while in atypical cases the hot spots were present only in the 48 hr picture. Twenty-one male volunteers were assessed. 18 of them had ACM (2 patients were studied repeatedly). The negative and positive control cases exhibited the expected Msc pattern. Seven ACM patients were regarded typically positive, in 5 cases atypical positivity was stated, and 6 patients were classified as Msc negatives. The heart lung activity ratio was 1.75 +/- 0.45 and 1.68 +/- 0.44 for typical and atypical positive cases, respectively. The control and DCM H/L ratios were 1.15 and 1.3 +/- 0.2, respectively, in AMI the H/L was 1.91, in DCM of dilatative phase it was 1.55 +/- 0.06 with serum myosin in the normal range. Heart dilation in the DCM groups: 5 dilated out of 7 typically positive cases while in atypically positive, and negative cases the dilation occurred in 2 out of 5 and 1 out of 6 cases, respectively. Low LV-EF (less than 45%) were found in ratios of 4/7, 2/5, and 1/6 in typically positive, atypically positive and negative cases, respectively. Elevated PCP similar ratios. In the same groups pathological ECG was seen in ratios of 5/7, 1/5, and 1/6, respectively. The g-GT activity was enhanced in all cases, there was, however, no evident correlation between the actual enzyme activity and intensity of hot accumulation.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2136360</PMID><DateCreated><Year>1992</Year><Month>09</Month><Day>14</Day></DateCreated><DateCompleted><Year>1992</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0237-6261</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>3-4</Issue><PubDate><Year>1990</Year></PubDate></JournalIssue><Title>Acta biochimica et biophysica Hungarica</Title><ISOAbbreviation>Acta Biochim. Biophys. Hung.</ISOAbbreviation></Journal><ArticleTitle>111-indium human antimyosin monoclonal antibody-fragment study on alcoholic (and diabetic) cardiomyopathic patients (ACM-DCM) with Centocor Europe Myoscint (Msc).</ArticleTitle><Pagination><MedlinePgn>165-73</MedlinePgn></Pagination><Abstract><AbstractText>The criteria of Msc-positivity were: typical accumulation of hot spots in 2 directions of planar scan in the 24-48-hr measurements, while in atypical cases the hot spots were present only in the 48 hr picture. Twenty-one male volunteers were assessed. 18 of them had ACM (2 patients were studied repeatedly). The negative and positive control cases exhibited the expected Msc pattern. Seven ACM patients were regarded typically positive, in 5 cases atypical positivity was stated, and 6 patients were classified as Msc negatives. The heart lung activity ratio was 1.75 +/- 0.45 and 1.68 +/- 0.44 for typical and atypical positive cases, respectively. The control and DCM H/L ratios were 1.15 and 1.3 +/- 0.2, respectively, in AMI the H/L was 1.91, in DCM of dilatative phase it was 1.55 +/- 0.06 with serum myosin in the normal range. Heart dilation in the DCM groups: 5 dilated out of 7 typically positive cases while in atypically positive, and negative cases the dilation occurred in 2 out of 5 and 1 out of 6 cases, respectively. Low LV-EF (less than 45%) were found in ratios of 4/7, 2/5, and 1/6 in typically positive, atypically positive and negative cases, respectively. Elevated PCP similar ratios. In the same groups pathological ECG was seen in ratios of 5/7, 1/5, and 1/6, respectively. The g-GT activity was enhanced in all cases, there was, however, no evident correlation between the actual enzyme activity and intensity of hot accumulation.(ABSTRACT TRUNCATED AT 250 WORDS)</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Horváth</LastName><ForeName>M</ForeName><Initials>M</Initials><Affiliation>State Hospital for Cardiology, Balatonfüred, Hungary.</Affiliation></Author><Author ValidYN="Y"><LastName>Pszota</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kármán</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Böszörményi</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Rakiás</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Bodor</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Pál</LastName><ForeName>T</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>HUNGARY</Country><MedlineTA>Acta Biochim Biophys Hung</MedlineTA><NlmUniqueID>8701158</NlmUniqueID><ISSNLinking>0237-6261</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Immunoglobulin Fab Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>138660-99-8</RegistryNumber><NameOfSubstance>imciromab pentetate</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.4.1</RegistryNumber><NameOfSubstance>Myosins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Alcoholism</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cardiomyopathy, Alcoholic</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Diabetes Mellitus</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Heart</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunoglobulin Fab Fragments</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lung</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Myocardial Infarction</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Myosins</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Organometallic Compounds</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2136360</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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